Relevance. The digital transformation of healthcare is becoming a key component of the national strategy for sustainable economic growth and increasing social protection of the population. It is changing the traditional forms of interaction between the state and society, increasing the transparency of management decisions and the involvement of citizens in decision-making processes.

The purpose of the study: to analyze the digital transformation of healthcare in the Kyrgyz Republic.

Materials and methods. A content analysis of the digital transformation of healthcare in the Kyrgyz Republic has been conducted. The materials of the scientific electronic libraries eLibrary, CyberLeninka, and the Internet were used, which are freely available and meet the criteria for inclusion for analysis (compliance with the selected research topic, full-text format of the work). The methods of analytical generalization, analogies, and formalization are applied.

Results. The level of digitalization of the economy and society in the Kyrgyz Republic can be described as low compared to the global average. The development of digital technologies is hindered not only by a lack of budget, but also by the weakness of the innovation sector, digital inequality between urban and rural areas, especially in geographically remote areas, as well as the lack of real-time access to data necessary for making managerial decisions. A set of measures has been developed for the active development and widespread introduction of modern information and communication technologies in the field of healthcare. The main initiatives include the Sanarip MED program aimed at digital transformation, covering electronic doctor appointments, digital patient records, vaccinations, laboratory diagnostics, statistics and monitoring.

Conclusion. Digitalization of healthcare plays a key role in improving the quality of life and accessibility of medical services in the Kyrgyz Republic. Investments in infrastructure, staff training, and improvements in the regulatory framework are needed to reach their full potential. Despite the difficulties, the introduction of digital technologies can significantly improve the quality of medical care for the population.

Relevance. In the Russian Federation, breast cancer is the most common cancer among women, with the highest incidence and mortality rate (approximately 15.5%). Mammography is the standard method for mass screening aimed at early detection of malignant breast tumors and ensuring timely and optimal treatment outcome.

The purpose of the study: to evaluate the effectiveness of double reading of mammograms using artificial intelligence (AI) technologies.

Materials and methods. An epidemiological study was conducted from 2015 to 2024 using the URIS UMIAS, annual reference books, and federal statistical monitoring forms. In 2023, double reading for mammography using AI was developed and implemented based on data from the Moscow Experiment.

Results. Comparison of active breast cancer detection rates revealed distinct dynamics. In Moscow, detected cases increased from 40.9% (2015) to 52.3% (2023), with a pandemic-induced decline to 18.5% (2021) and post-COVID recovery at 9.6%/year. Nationwide, rates rose steadily from 37.2% to 44% (2.5%/year), without significant contrasts. The introduction of double reading of mammography AI decisively contributed to the significant, sustainable increase in active detection of breast cancer patients.

Conclusion. Artificial intelligence-enabled medical devices are recommended for transforming the double reading of mammography. Long-term implementation ensures a significant, sustainable increase in active detection of women with malignant breast tumors.

Relevance. In the context of modernizing Uzbekistan’s healthcare system, a clear differentiation between the roles of the manager and the administrator, their functional specialization, and professional development is of particular importance. The article systematizes the concept of the manager and the administrator in healthcare, analyzes their functions, levels of responsibility, and current practices in international healthcare systems, including countries in Europe and North America. Special attention is paid to modern trends and innovations: the implementation of digital technologies, the value-based healthcare model, the formation of multidisciplinary teams, and risk management.

The purpose of the study: to systematize the concepts of the administrator and the manager, reveal the functional differences between them, define the levels of responsibility, and analyze current international practices in the field of healthcare management.

Materials and methods. The study utilized materials from the scientific electronic library PubMed and open-access internet resources. The analytical method and content analysis were applied.

Results. Based on international experience, practical recommendations for Uzbekistan are proposed, including the implementation of digital platforms, strategic planning, process optimization, and human resource development. The necessity of postgraduate training for a new generation of administrators at the Department of Public Health and Healthcare Management is emphasized, aimed at developing strategically thinking and competent leaders capable of ensuring the efficiency, sustainability, and innovative development of the country’s healthcare system.

Conclusion. Professional development and postgraduate training of a new generation of administrators at the Department of Public Health and Healthcare Management is an essential condition for the successful modernization of Uzbekistan’s healthcare system and its integration into the global medical community. Uzbekistan will be able to achieve high efficiency in its healthcare system, improve the population’s quality of life, and meet modern international standards, particularly through the training of strategically thinking, competent, and innovation-oriented administrators.

Relevance. Circulatory system diseases remain the leading cause of death worldwide. Current research points to the need to go beyond traditional biological risk factors and account for socially distress determinants – social conditions that cause chronic stress (economic inequality, working conditions, social exclusion) which have a significant impact on cardiovascular health.

The purpose of the study: conduct a comprehensive analysis of global trends and regional approaches to the study and management of social-distress determinants for circulatory system diseases prevention in 2021–2025.

Materials and methods. A systematic analysis of scientific literature and official documents for 2021–2025 has been carried out. Searches were conducted in PubMed, MEDLINE, Google Scholar, eLIBRARY.ru, and resources from the WHO, the European Society of Cardiologists, and the American Association of Cardiology. The final analysis includes sources including original studies, systematic reviews, clinical guidelines and analytical reports. Comparative and content-analysis methods are applied.

Results. The increasing influence of macro crises (COVID‑19 pandemic, climate change) as a super-determinant has been identified, worsening social gradient in BSC outcomes and causing a global rise in psychological distress. Established a trend for integrating mental health into cardiac care (recommendations of the European Society of Cardiologists 2021/2023). The focus of prevention is shifted to creating a health-saving environment through fiscal and urban policies (“health in all policies”). Comparative analysis of regional strategies for managing social-distress determinants in Europe (social purpose), North America (standardized screening), Asia (air pollution control, corporate programs) and low-income countries (community projects, mhGAP programme). Methodological aspects of the assessment of social-distress determinants are highlighted, including questions of validation of complex surveys through verification of convergent validity with international scales (WHOQOL-BREF, PSS, SCORE2).

Conclusion. Period 2021–2025 was marked by a shift from accumulating knowledge about the harm of social-distress determinants to actively implementing practical strategies for their nivelling. The prospects are linked to the personalization of prevention and intersectoral cooperation. Key challenges remain industrial lobby resistance, the difficulty of assessing long-term efficiency, and the risks of digital inequality. Taking into account social context is a prerequisite for reducing the global burden of circulatory disease.

Relevance. In the current demographic situation in the Russian Federation, the assessment of the influence of various medical and social factors on the reproductive behavior of the adult population and the decision to have a first child is of great social and economic importance. Motivational factors include socio-economic and biological factors, such as the age of the woman, the number of children already born (if there is one child in the family, there is a higher probability of having second and third children), the presence of a permanent partner, registered marriage, ownership of real estate, stable income, and the employment of the spouse. Religious beliefs are also of great importance.

The purpose of the study: is to analyze the motivational and barrier factors affecting the reproductive behavior of the adult population of the Russian Federation.

Materials and methods. In 2025, the Russian Research Institute of Health conducted an observational one-stage study to assess the reproductive behavior and reproductive attitudes of citizens of the Russian Federation and identify the factors influencing them, using a questionnaire that included 63 questions divided into four blocks. The study results were statistically processed using Statistica for Windows version 10.0, Stata, and R-studio.

Results. A total of 1,625 respondents over the age of 18 (44.8% of men and 55.2% of women) from 85 regions of the Russian Federation took part in the survey. Percentage of respondents of fertile age (18–49 years old) It was 67.7%. Respondents' answers about which factors had the strongest influence on the decision to have their first child were distributed as follows: personal desire (78.8%), financial stability (64.1%), having their own home (63.8%), health status (70.3%) and partner support (70.7%). Religious principles (56.0%) and environmental pressure (51.2%) influenced only half of the cases. Heterogeneity has been revealed in the context of federal districts in terms of the influence of various factors on the decision on the birth of the first child by women of fertile age.

Conclusion. The reproductive behavior of men and women of fertile age has a decisive impact on the birth rate in the Russian Federation. The data obtained during the study highlight the need for a comprehensive approach to correcting the demographic situation within the framework of the national project "Family".

Relevance. He growth of chronic non-communicable diseases remains one of the leading problems of modern healthcare. The effectiveness of preventive activities of medical organizations has an impact on the level of morbidity, disability and mortality of the population.

The purpose of the study: to analyze the organization of preventive activities of a medical organization and identify the limitations of its implementation in the context of the growth of chronic non-communicable diseases.

Materials and methods. An organizational retrospective study was conducted on the basis of a primary health care medical organization for 2020–2025. The indicators of outpatient follow-up of patients with arterial hypertension, chronic heart failure and diabetes mellitus are analyzed. The methods of descriptive statistics, dynamic series analysis, and organizational audit were used.

Results. The number of the attached population increased from 258,395 to 295,899 people. The prevalence of arterial hypertension increased from 3,081 to 4,933 cases per 100,000 population, chronic heart failure – from 115 to 402, diabetes mellitus – from 1,351 to 2,009 cases per 100,000 population. Preventive activities are characterized by the predominance of informational forms of work with limited development of structured preventive programs and insufficient staffing.

Conclusion. A discrepancy has been established between the growth of chronic pathology and the level of organizational readiness of the preventive service. It is necessary to strengthen human resources and introduce structured prevention programs.